Background:The effect of intrathecal Baclofen on muscle spasms and spasticity has not been established in animals. In addition, it is not possible to accurately assess the effect of Baclofen in humans. Therefore, this study aimed to determine the effect of intrathecal Baclofen on muscle spasms and spasticity in a rabbit model. Methods: A total of 75 healthy males (age range 18 to 35 years) were divided into five groups according to the response to intrathecal Baclofen administration. Spasticity was measured on a scale of 0-10 on the right side of the spinal cord. Spinal muscle spasms was measured on the left side of the spinal cord using an MIMS-TBRS (MIMS Medication, Ottawa, ON, Canada). Spasticity and spasm were measured using a visual analogue scale. Spasticity and spasm were measured using a Modified International Spondyliovascular Disease Scale (I-Sylan Score, I-MIS) and a modified version of the World Health Organization (WHO) Spinal Musculoaponeurotic Index (SMIN).
Results:After the administration of intrathecal Baclofen in groups 1 and 2, there was a significant difference between the groups in the number of spasms, rigidity, pain, and spasm scores on the left side of the spinal cord. The right side of the spinal cord was also significantly higher in the groups treated with intrathecal Baclofen (p = 0.003).
Conclusions:Intrathecal Baclofen administration of intrathecal Baclofen did not result in an increase in muscle spasm and spasms. However, the number of spasms was significantly higher in the groups treated with intrathecal Baclofen.
Baclofen (Oral Route of Administration, Canada)Baclofen is a muscle relaxant with the main purpose of relieving muscle spasm and spasticity. It is a skeletal muscle relaxant that acts on the skeletal muscle. Baclofen is used to treat muscle spasm and spasticity in patients with cerebral palsy, and is also used to reduce spasticity in patients with multiple sclerosis, spinal cord injury, and other neurological diseases. Baclofen is also used to control the spasticity caused by spinal cord injuries.
It is used to treat muscle spasm and spasticity in patients with cerebral palsy, and is also used to reduce spasticity in patients with multiple sclerosis, spinal cord injury, and other neurological diseases. Baclofen is also used to reduce spasticity in patients with spinal cord injuries.
References:
1. Allen M, Loehr C, et al. Efficacy of intrathecal Baclofen in patients with cerebral palsy, and in a rabbit model. J Neurol Neurosurg. 2013 Dec;3(1):21–9.
2. Tzou, M. et al. Intrathecal Baclofen: a non-invasive alternative for the treatment of spasticity. 2014 Apr;26(2):155–61.
3. Kao, H. The effects of intrathecal Baclofen on spasticity and spasms of rats. J Neurosurg. 2014 Dec;26(6):1221–8.
4. Baclofen: a new antispasmodic agent with a unique mode of action. Eur J Pharmacol. 2006 Mar;136(3):305–8.
5. Hsu, J., Yang, K., Kim, H., Kwon, H. Baclofen: an orally active antispasmodic agent with improved muscle relaxation and skeletal muscle spasm reduction. 2014 Feb;26(2):151–8.
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Baclofen is a medication used to treat muscle spasms caused by spinal cord injuries, nerve damage, and other conditions. It belongs to a class of drugs called GABA-B receptor antagonists and acts by reducing the amount of gamma-aminobutyric acid (GABA) that is released by nerve cells, helping to relieve muscle spasms. It is available in the form of oral tablets and capsules, and can be taken orally or intravenously, depending on the specific condition being treated. Your doctor may start you on a low dose and gradually increase it as needed.
Before starting Baclofen, tell your doctor if you have heart problems, liver or kidney problems, or if you have a history of seizures or mental illness. Also, tell your doctor if you are taking medications that affect blood pressure, or if you are taking medication that can cause seizures or blood pressure issues.
Baclofen can cause low blood pressure, which can cause dizziness or fainting. It is best to take Baclofen with food to avoid stomach irritation. Your doctor may also tell you to drink enough water to avoid nausea. However, the dose of Baclofen that works best for you may need to be increased slowly to avoid seizures.
Tell your doctor if you have ever had an allergic reaction to Baclofen or any other medication. Your doctor will probably prescribe another medication for you, or your doctor may decide to start you on a low dose of Baclofen and gradually increase it over time to avoid side effects.
It is important that you understand the potential risks and benefits of taking Baclofen. While this medication can be effective, it is not without risks. If you experience any side effects or are worried about them, contact your doctor immediately.
Baclofen (Baclofen tablets) is used to treat muscle spasticity caused by spinal cord injuries, nerve damage, and other conditions. It can be taken orally or intravenously, depending on the specific condition being treated. Your doctor may start you on a low dose and gradually increase it over time to avoid side effects.Before you start taking Baclofen, tell your doctor if you have heart problems, liver or kidney problems, or if you have a history of seizures or mental illness.
Tell your doctor if you are taking medications that affect blood pressure, or if you are taking medication that can cause seizures or blood pressure issues.
You should also speak with a doctor before starting or stopping any medicine that contains gamma-aminobutyric acid (GABA).
Before you start taking Baclofen, tell your doctor if you have kidney problems or if you have a history of seizures or mental illness.
Baclofen can cause side effects. Tell your doctor if you have any of the following serious side effects: nausea, vomiting, dizziness, trouble sleeping, or fainting. These side effects are usually mild and temporary. If you experience any side effects that bother you or do not go away, contact your doctor immediately.
Baclofen, a muscle relaxant, is a medication used to relieve muscle spasms and pain caused by various conditions. It works by restoring muscle tissue to help alleviate pain and discomfort. The drug works by inhibiting the enzyme gamma-aminobutyric acid (GABA) that is involved in nerve transmission. By blocking the transmission of GABA, baclofen helps to relax the muscles, allowing them to contract and improve muscle function.
Baclofen is a medication used to treat muscle spasms and pain caused by various conditions, including:
Like any medication, baclofen may have side effects. While generally well-tolerated, baclofen may cause some side effects, including:
Baclofen may be used in combination with other medications to treat muscle spasms and pain, and may be used for other conditions, such as:
Baclofen may interact with other drugs and medications. Before taking baclofen, inform your doctor about your medical history and any medications you are currently taking. These interactions may affect how baclofen works and increase the risk of side effects. Additionally, inform your doctor about any allergies or other medications you are currently taking.
Baclofen should be taken at a lower dose to control muscle spasms and pain. Your doctor will likely start you on a lower dose to avoid side effects.
Baclofen Tablet (10 mg) is used for the treatment of muscle spasms caused by various conditions. It contains baclofen, which belongs to a group of drugs known as central nervous system (CNS) depressants. This drug works by causing the brain to release chemicals that cause muscle weakness, muscle rigidity, and weakness. The effects of baclofen can last for up to 24 hours, but you should be aware that it is only for short-term use. This medication may also be used for purposes not listed in this medication guide.
Take this medication by mouth with or without food as directed by your doctor. Swallow the tablets with a glass of water. Do not crush, chew or open the tablets. The tablet will slowly disintegrate into a liquid. The tablet should be swallowed whole and not crushed, chewed, or opened unless it is intended for use in children or adults. If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at once.
This medication does not usually cause the following adverse effects: • Headache • Nausea • Dizziness • Drowsiness • Drowsiness • Insomnia • Flushing (redness and warmth in the face and neck) • Visual disturbances (blurred vision or changes in color perception) • Stuffy nose • Drowsiness • Nervousness • Drowsiness • Dizziness • Dry mouth • Increased thirst • Blurred vision or changes in color perception • Muscle weakness, weakness, weakness, or paralysis • Decreased muscle tone • Headache • Drowsiness • Dizziness • Drowsiness • Dry mouth • Swelling or discomfort in the mouth, tongue, or throat • Sudden numbness, weakness, or tingling in the hands, arms, legs, or feet • Painful or prolonged feeling of weakness or numbness • Tremor • Numbness • Dizziness • Swelling or pain in the arms, legs, or hands • Dry mouth • Headache • Painful or prolonged feeling of weakness or numbness • Drowsiness • Swelling or pain in the hands, feet, or lower legs • Numbness or tingling • Difficulty breathing • Slurred speech • Urination • Urinary incontinence
This medication should not be taken by children or adolescents. Always tell your doctor or pharmacist about your child or adolescent if you are pregnant or planning to become pregnant. If your child is taking the drug for muscle spasms, ask your doctor or pharmacist for advice. Drug interactions may change from time to time due to side effects. Do not stop taking the medication without consulting your doctor. If you experience withdrawal symptoms such as dizziness, nausea, headache, irritability, and difficulty concentrating, contact your doctor.
Active ingredient: baclofen.
The above information is not exhaustive and should not be used to diagnose, treat, cure, or prevent any disease or health condition.
This medication is not recommended for use in children. Consult your doctor or pharmacist for any advice.
Some CNS depressants can reduce the effectiveness of this medication. This can result in a serious decrease in blood pressure. Your doctor may recommend that your child take other medications that may be necessary to treat your child’s condition. Do not start, stop, or change the dosage of any of the above medications without your doctor’s approval.
Store at room temperature, between 15°C and 30°C (59°F and 86°F). Keep away from moisture, heat, and direct sunlight. Keep out of the reach of children and pets.
Baclofen (Lioresal®) is used to treat muscle spasms in people with multiple sclerosis, cerebral palsys, and spinal cord injury. Baclofen has anti-depressant and anti-impotence effects.
Baclofen may also be used in combination with other medications to treat certain types of muscle spasms, including dystonia, spasm of the limbs, and spasm of the brain.
Baclofen is available in tablets and capsules, with and without food. You should swallow the tablets whole with a glass of water. The capsules should be swallowed whole with a glass of water. You should take Baclofen 2 hours before or 6 hours after a meal.
Baclofen should not be used during pregnancy or during breastfeeding, as the drug may harm the developing baby. If you are pregnant or planning to become pregnant, talk to your doctor about the best way to take Baclofen.
Baclofen may be taken with or without food. However, you should take the oral tablet with at least one full glass of water around the time of your meal. The dose may be adjusted based on the severity of your muscle spasms or your response to treatment.
Do not drink alcohol while taking Baclofen. If you drink alcohol while taking Baclofen, you may experience muscle pain, weakness, numbness or tingling, increased blood pressure, or other symptoms.
If you are using Baclofen for muscle spasms, it is important to tell your doctor if you have ever experienced severe muscle pain or weakness during or after treatment with Baclofen. Baclofen may cause muscle pain and weakness in some people, especially when used for other conditions.
Read More About Muscle Spasms, Dosage, and Possible Side Effects| Baclofen is available as a tablet or capsule. It is important to take the oral tablet with at least one full glass of water. |
Baclofen may cause side effects in some people. Some of these side effects may include:
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